Journal
BIOMACROMOLECULES
Volume 18, Issue 4, Pages 1210-1217Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.6b01887
Keywords
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Funding
- National Natural Science Foundation of China [21525420, 21374107]
- China Postdoctoral Science Foundation [BH2060000011]
- Fundamental Research Funds for the Central Universities [WK 2060200012, WK 2060200015]
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An ingenious formulation of RAFT dispersion polymerization based on photosensitive monomers of 2-nitrobenzyl methacrylate (NBMA) and 7-(2-methacryloyloxy-ethoxy)-4-methyl-coumarin (CMA) is reported herein. Various morphologies, such as spherical micelle, nanoworm, lamella, and vesicle, are fabricated at up to 20% solids content. Photoinduced cleavage of the NBMA moieties and dimerization of the coumarin moieties are simultaneously triggered upon UV (365 nm) irradiation. The former endows the cores of the nano-objects with abundant carboxyl groups, resulting in the transformation of the hydrophobic cores to hydrophilic ones. The latter induces the core-cross-linking of the nano objects, which endows the nano-objects with enhanced structural stability and prevents the nanoparticle-to-unimer disassembly. The resultant nano-objects exhibit superior structural stability and excellent performances for drug delivery, including high drug loadings, pH-stimuli release, and high-efficient endosomal escape.
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