Journal
CHEMISTRY & BIODIVERSITY
Volume 14, Issue 4, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201600297
Keywords
Delphinium tianshanicum; C-19-Diterpenoid alkaloids; Cytotoxic activities; Tianshanitines
Funding
- National Natural Foundation of China [81402803]
- Research Foundation for the Educational Commission of Sichuan Province [15TD0048]
- Fundamental Research Funds for the Central Universities [2682015ZT04]
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Five new diterpenoid alkaloids, tianshanitines A-E (1-5), along with ten known compounds (6-15), were isolated from the EtOH extracts of the whole plant of Delphinium tianshanicum W.T.Wang. Their structures were determined based on extensive spectroscopic analyses, including 1D- and 2D-NMR, HR-ESI-MS, and the structure of tianshanitine C (3) was confirmed by X-ray diffraction analysis. Tianshanitine A (1) is the first example of natural diterpenoid alkaloid containing a benzoyl group at C(1) position. Tianshanitine B (2) is a rare natural diterpenoid alkaloid bearing a OH group at C(16) position. Compounds 1-5, 6, 8, 10, 12 and 14 were evaluated for cytotoxicity against HCT116, MCF-7 and HepG2 human cancer cell lines.
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