Journal
DRUG DISCOVERIES AND THERAPEUTICS
Volume 11, Issue 2, Pages 110-114Publisher
INT RESEARCH & COOPERATION ASSOC BIO & SOCIO-SCIENCES ADVANCEMENT
DOI: 10.5582/ddt.2017.01011
Keywords
Propolis; sea cucumber; frondoside A; nymphaeols; PAK1; cancers
Categories
Funding
- fishing company Jinsho, Japan
- Grants-in-Aid for Scientific Research [15K07436] Funding Source: KAKEN
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A sulfated saponin called Frondoside A (FRA) from sea cucumber and ingredients from Okinawa propolis (OP) have been previously shown to suppress the PAK1-dependent growth of A549 lung cancer as well as pancreatic cancer cells. However, the precise molecular mechanism underlying their anti-cancer action still remains to be clarified. In this study, for the first time, we found that both FRA and OP directly inhibit PAK1 in vitro in a selective manner (far more effectively than two other oncogenic kinases, LIMK and AKT). Furthermore, at least two major anti-cancer ingredients of OP, nymphaeols A and C, also directly inhibit PAK1 in vitro in a selective manner. To the best of our knowledge, FRA is the first marine compound that selectively inhibits PAK1. Likewise, these nymphaeols are the first propolis ingredients that selectively inhibit PAK1.
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