4.7 Article

NMR signal enhancement of > 50 000 times in fast dissolution dynamic nuclear polarization

Journal

CHEMICAL COMMUNICATIONS
Volume 53, Issue 26, Pages 3757-3760

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc00635g

Keywords

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Funding

  1. Intramural Project CIBER-BBN ORDECA''
  2. DGI Grants [CTQ2013-40480-R, MAT2016-80826-R, BIO2013-45793-R, BIO2016-78006-R]
  3. AGAUR Grant [2014SGR-0017]
  4. Spanish MINECO through the Severo Ochoa Centres of Excellence Programme Grant [SEV-2015-0496]

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Herein, we report the synthesis and the study of a novel mixed biradical with BDPA and TEMPO radical units that are covalently bound by an ester group (BDPAesterTEMPO) as a polarizing agent for fast dissolution DNP. The biradical exhibits an extremely high DNP NMR enhancement of > 50000 times, which constitutes one of the largest signal enhancements observed so far, to the best of our knowledge.

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