4.7 Article

Room-temperature synthesis of core-shell structured magnetic covalent organic frameworks for efficient enrichment of peptides and simultaneous exclusion of proteins

Journal

CHEMICAL COMMUNICATIONS
Volume 53, Issue 26, Pages 3649-3652

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc00482f

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Funding

  1. National Natural Science Foundation of China [21375018, 21675025]
  2. Program for Changjiang Scholars and Innovative Research Team in University [IRT15R11]
  3. Hong Kong Research Grant Council [C2024-14EF]

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Core-shell structured magnetic covalent organic frameworks (Fe3O4@COFs) were synthesized via a facile approach at room temperature. Combining the advantages of high porosity, magnetic responsiveness, chemical stability and selectivity, Fe3O4@COFs can serve as an ideal absorbent for the highly efficient enrichment of peptides and the simultaneous exclusion of proteins from complex biological samples.

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