4.8 Article

Engineered Multifunctional Nanomedicine for Simultaneous Stereotactic Chemotherapy and Inhibited Osteolysis in an Orthotopic Model of Bone Metastasis

Journal

ADVANCED MATERIALS
Volume 29, Issue 13, Pages -

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201605754

Keywords

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Funding

  1. National Natural Science Foundation of China [21671198, 21425103, 81401464, 21501192]
  2. National Key Research and Development Program of China [2016YFA0101503]
  3. Natural Science Foundation of Jiangsu Province [BE2016682]
  4. Youth Innovation Promotion Association of Chinese Academy of Sciences (CAS)

Ask authors/readers for more resources

A novel multifunctional Ag2S quantum dot (QD)-based nanomedicine of alendronate (Ald)/doxorubicin (DOX)@Ag2S is developed for highly effective bone tumor therapy in an orthotopic model. The bone-targeting and osteolysis inhibition of Ald and the chemotherapeutic effect of DOX on the bone tumor are in situ visualized by Ag2S QDs with emission in the second near-infrared window.

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