Journal
PLOS GENETICS
Volume 13, Issue 2, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1006613
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Funding
- Howard Hughes Medical Institute
- Computational Neuroscience Training Grant (CNTG) [R90 DA033463]
- NIH (NINDS) [R01NS077933]
- NSF (IOS) grant [1354046]
- Direct For Biological Sciences [1354046] Funding Source: National Science Foundation
- Division Of Integrative Organismal Systems [1354046] Funding Source: National Science Foundation
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Locomotor activity rhythms are controlled by a network of similar to 150 circadian neurons within the adult Drosophila brain. They are subdivided based on their anatomical locations and properties. We profiled transcripts around the clock from three key groups of circadian neurons with different functions. We also profiled a non-circadian outgroup, dopaminergic (TH) neurons. They have cycling transcripts but fewer than clock neurons as well as low expression and poor cycling of clock gene transcripts. This suggests that TH neurons do not have a canonical circadian clock and that their gene expression cycling is driven by brain systemic cues. The three circadian groups are surprisingly diverse in their cycling transcripts and overall gene expression patterns, which include known and putative novel neuropeptides. Even the overall phase distributions of cycling transcripts are distinct, indicating that different regulatory principles govern transcript oscillations. This surprising cell-type diversity parallels the functional heterogeneity of the different neurons.
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