Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 26, Pages 3697-3700Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc00700k
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Funding
- National Institute of Health [1R15EB014546-01A1]
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An NIR-emitting probe (lambda(em) similar to 700 nm) with a large Stokes shift (Delta lambda approximate to 234 nm) is synthesized by using excited-state intramolecular proton transfer (ESIPT). The phenolic proton, which controls ESIPT, acts as a switch to give strong fluorescence at pH approximate to 5. The probe can selectively show lysosome organelles, therefore leading to a lysosome probe without exhibiting an alkalinizing effect''.
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