Journal
BIOLOGICAL PSYCHIATRY
Volume 81, Issue 5, Pages 383-390Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2016.08.031
Keywords
Autism; Autoimmunity; Immune; Maternal autoantibodies; Neurodevelopmental; Pregnancy
Categories
Funding
- National Institute of Environmental Health Sciences (NIEHS) Center [2P01ES011269-11, 83543201]
- NIEHS [R01ES015359]
- National Institute of Child Health and Human Development [U54HD079125]
- Pediatric Bioscience
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Auism spectrum disorder (ASD) now affects one in 68 births in the United States and is the fastest growing neurodevelopmental disability worldwide. Alarmingly, for the majority of cases, the causes of ASD are largely unknown, but it is becoming increasingly accepted that ASD is no longer defined simply as a behavioral disorder, but rather as a highly complex and heterogeneous biological disorder. Although research has focused on the identification of genetic abnormalities, emerging studies increasingly suggest that immune dysfunction is a viable risk factor contributing to the neurodevelopmental deficits observed in ASD. This review summarizes the investigations implicating autoimmunity and autoantibodies in ASD.
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