Journal
PLOS BIOLOGY
Volume 15, Issue 12, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.2002800
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Funding
- National Institute of Environmental Health Sciences [R01 ES024381, R01 ES020349, R01 ES021357]
- National Institutes of Health-Office of the Director [UG3 OD023313]
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Epidemiological studies play an important role in quantifying how early life environmental chemical exposures influence the risk of childhood diseases. These studies face at least four major challenges that can produce noise when trying to identify signals of associations between chemical exposure and childhood health. Challenges include accurately estimating chemical exposure, confounding from causes of both exposure and disease, identifying periods of heightened vulnerability to chemical exposures, and determining the effects of chemical mixtures. We provide recommendations that will aid in identifying these signals with more precision.
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