Journal
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
Volume 17, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12906-017-1584-8
Keywords
Atopic dermatitis; Angelicae dahuricae Radix; 2,4-Dinitrocholrlbenzene; BALB/c mice; Cytokine; Inflammation
Categories
Funding
- Korean Medicine R&D Project of the Ministry of Health and Welfare [HI12C1889, HI13C0530]
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Background: Atopic dermatitis (AD) is an inflammatory, chronically relapsing, and intensively pruritic skin disease that affect 10-30% of the global population. Angelicae dahuricae Radix (ADR) has been reported to be anti-inflammatory in Korean Medicine. In the present study, we investigated whether ADR suppresses the progression of AD in animal model. Methods: AD was induced by 2, 4-Dinitrochlorobenzene (DNCB). ADR was orally administered to mice to study the effect of ADR on AD. Histological Analysis, immunohistochemistry, blood analysis, RT-PCR, and ELISA assay were performed. Results: ADR significantly suppressed AD-like symptoms in BALB/c mice: ADR decreased skin thickness and spleen weight of mice. ADR reduced infiltration of mast cells, inflammatory cells and CD4+ cells into mouse skin. ADR lowered the number of WBCs in the blood of mice. ADR reduced the levels of IgE, IL-6, IL-10 and IL-12 in mice serum. ADR down-regulated mRNA expression of IL-4, IL-6 and TNF-alpha in mouse skin tissue. Conclusion: Our present study clearly indicates that ADR suppresses the progression of AD induced by DNCB in BALB/c mice. This suggests that ADR might be a useful drug for the treatment of AD.
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