Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 45, Issue -, Pages 229-236Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20160387
Keywords
-
Categories
Funding
- National Institutes of Health Grant [GM117916]
- Vanderbilt University
Ask authors/readers for more resources
Cancer-associated fibroblasts (CAFs) are major components of the surrounding stroma of carcinomas that emerge in the tumor microenvironment as a result of signals derived from the cancer cells. Biochemical cross-talk between cancer cells and CAFs as well as mechanical remodeling of the stromal extracellular matrix (ECM) by CAFs are important contributors to tumor cell migration and invasion, which are critical for cancer progression from a primary tumor to metastatic disease. In this review, we discuss key paracrine signaling pathways between CAFs and cancer cells that promote cancer cell migration and invasion. In addition, we discuss physical changes that CAFs exert on the stromal ECM to facilitate migration and invasion of cancer cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available