3.8 Article

Isolation of Lupeol, Design and Synthesis of Lupeol Derivatives and their Biological Activity

Journal

ORIENTAL JOURNAL OF CHEMISTRY
Volume 33, Issue 1, Pages 173-180

Publisher

ORIENTAL SCIENTIFIC PUBL CO
DOI: 10.13005/ojc/330119

Keywords

Walsura trifoliata; Lupeol; oxime ester derivatives

Funding

  1. Divis laboratories

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The triterpenoid, lupeol (1) has been isolated from the leaves extract of Walsura trifoliate. Few novel derivatives (4a-j) were synthesized from the naturally occurring lupeol (1) and confirmed by spectroscopic methods, and tested for antimicrobial and anti-proliferative activity against MDAMB-231, IMR32and A549 cell lines. This all compound showed moderate activities.

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