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Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit
LE Littlepage et al.
GENES & DEVELOPMENT (2002)
APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit
R Wäsch et al.
NATURE (2002)
Segregating sister genomes: The molecular biology of chromosome separation
K Nasmyth
SCIENCE (2002)
Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1
A Hagting et al.
JOURNAL OF CELL BIOLOGY (2002)
The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2
R Grosskortenhaus et al.
DEVELOPMENTAL CELL (2002)
Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit
SWN Au et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box
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EMBO JOURNAL (2001)
Dual inhibition of sister chromatid separation at metaphase
O Stemmann et al.
CELL (2001)
APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex
ZY Tang et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Cell cycle-dependent degradation of the Saccharomyces cerevisiae spindle motor Cin8p requires APCCdh1 and a bipartite destruction sequence
ER Hildebrandt et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC
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EMBO JOURNAL (2001)
Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex
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GENES & DEVELOPMENT (2001)
D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p
JL Burton et al.
GENES & DEVELOPMENT (2001)
The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner
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CURRENT BIOLOGY (2001)
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
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JOURNAL OF CELL BIOLOGY (2001)
Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex
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NATURE STRUCTURAL BIOLOGY (2001)
A complex degradation signal in Cyclin A required for G1 arrest, and a C-terminal region for mitosis
HW Jacobs et al.
EMBO JOURNAL (2001)
Cyclin a is destroyed in prometaphase and can delay chromosome alignment and anaphase
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JOURNAL OF CELL BIOLOGY (2001)
Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin a starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
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JOURNAL OF CELL BIOLOGY (2001)
Three-dimensional structure of the anaphase-promoting complex
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MOLECULAR CELL (2001)
Ama1p is a meiosis-specific regulator of the anaphase promoting complex/cyclosome in yeast
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast
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CELL (2000)
The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
The APC11 RING-H2 finger mediates E2-dependent ubiquitination
JD Leverson et al.
MOLECULAR BIOLOGY OF THE CELL (2000)
Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex
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JOURNAL OF CELL BIOLOGY (2000)
Phosphorylation of Cdc20/Fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Mitotic regulation of the APC activator proteins CDC20 and CDH1
ER Kramer et al.
MOLECULAR BIOLOGY OF THE CELL (2000)
CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis
E Noton et al.
MOLECULAR CELL (2000)
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