Journal
OPEN BIOLOGY
Volume 7, Issue 6, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsob.170073
Keywords
snRNA; transcription; RNA processing; Integrator; Mediator
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Funding
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) from the Brazilian Government [201323/2015-0]
- Wellcome Trust [WT106134AIA]
- MRC [MR/M010716/1, G0400653] Funding Source: UKRI
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In addition to protein-coding genes, RNA polymerase II (pol II) transcribes numerous genes for non-coding RNAs, including the small-nuclear (sn)RNA genes. snRNAs are an important class of non-coding RNAs, several of which are involved in pre-mRNA splicing. The molecular mechanisms underlying expression of human pol II-transcribed snRNA genes are less well characterized than for protein-coding genes and there are important differences in expression of these two gene types. Here, we review the DNA features and proteins required for efficient transcription of snRNA genes and co-transcriptional 30 end formation of the transcripts.
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