Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2016, Issue 3, Pages 438-442Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201501502
Keywords
Copper; Heterocycles; 1, 2, 4-Oxadiazoles; Homogeneous catalysis; Cyclization
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Funding
- Institute for Basic Science [IBS-R022-D1-2015]
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Herein, we report the first Cu-catalyzed one-step method for the synthesis of 1,2,4-oxadiazoles from stable, less toxic, and readily available amides and organic nitriles by a rare oxidative N-O bond formation using O-2 as sole oxidant. This method has a broad substrate scope and a good tolerance for diverse functional groups. Moreover, the synthetic utility of this method is highlighted by the synthesis of biologically active 3,5-disubstituted derivatives.
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