Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2015, Issue 20, Pages 4295-4309Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201500231
Keywords
Synthetic methods; Fluorine; Aminofluorination; Amines; Nitrogen heterocycles; Alkenes
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Funding
- National Basic Research Program of China [973-2011CB808700]
- National Nature Science Foundation of China (NSFC) [21225210, 21202185, 21121062]
- Science and Technology Commission of the Shanghai Municipality [12ZR1453400]
- CAS/SAFEA International Partnership Program for Creative Research Teams
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Direct aminofluorination of alkenes enables the convenient synthesis of beta-fluorinated amine compounds, which are important and valuable skeletons in medicinal chemistry. In recent years this research field has received much attention and significant advancements have been made by different approaches. In this review, recently disclosed methodologies for the production of beta-fluorinated amines, based on electrophilic and metal-catalyzed processes, are summarized and discussed. Finally, the outlook and perspectives for aminofluorination are also discussed.
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