Journal
MRS COMMUNICATIONS
Volume 7, Issue 3, Pages 375-382Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1557/mrc.2017.45
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Funding
- Swiss National Science Foundation [P2BEP3_152091, P300PB_161072]
- British Heart Foundation Cardiovascular Regenerative Medicine Centre [RM/13/1/30157]
- EPSRC Centre for Doctoral Training under the Centre for Plastic Electronics, Imperial College London [EP/G037515/1]
- H2020 through the RAISED [660757]
- UK Regenerative Medicine Platform Hubs 'Acellular Approaches for Therapeutic Delivery' [MR/K026682/1]
- MRC [MR/L012677/1]
- ERC Seventh Framework Programme [616417]
- EPSRC [EP/J021199/1] Funding Source: UKRI
- MRC [MR/K026682/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/J021199/1] Funding Source: researchfish
- Medical Research Council [MR/K026682/1, MR/L012677/1] Funding Source: researchfish
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Conjugated polymers have been proposed as promising materials for scaffolds in tissue engineering applications. However, the restricted processability and biodegradability of conjugated polymers limit their use for biomedical applications. Here we synthesized a block-co-polymer of aniline tetramer and PCL (AT-PCL), and processed it into fibrous non-woven scaffolds by electrospinning. We showed that fibronectin (Fn) adhesion was dependent on the AT-PCL oxidative state, with a reduced Fn unfolding length on doped membranes. Furthermore, we demonstrated the cytocompatibility and potential of these membranes to support the growth and osteogenic differentiation of MC3T3-E1 cells over 21 days.
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