Journal
BIOPHYSICAL JOURNAL
Volume 112, Issue 4, Pages 703-713Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2016.12.047
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Funding
- National Institutes of Health (NIH) [5R0IEB000312]
- Binational Science Foundation (BSF) [2010382,]
- University of California Los Angeles-Department of Energy Institute for Genomics and Proteomics (UCLA-DOE Institute for Genomics and Proteomics) [DE-FCO2-02ER63421]
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Voltage-sensing dyes and voltage-sensing fluorescence proteins have been continually improved and as a result have provided a wealth of insights into neuronal circuits. Further improvements in voltage-sensing dyes and voltage-sensing fluorescence proteins are needed, however, for routine detection of single action potentials across a large number of individual neurons in a large field-of-view of a live mammalian brain. On the other hand, recent experiments and calculations suggest that semiconducting nanoparticles could act as efficient voltage sensors, suitable for the above-mentioned task. This study presents quantum mechanical calculations, including Auger recombination rates, of the quantum-confined Stark effect in membrane embedded semiconducting nanoparticles, examines their possible utility as membrane voltage sensors, and provide design rules for their structure and composition.
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