Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2015, Issue 27, Pages 5919-5924Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201500986
Keywords
Synthetic methods; Iodine; Iodane synthesis; Iodonium salts; Aryl iodides; Oxidation
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Funding
- Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health [R01 EB015536]
- National Natural Science Foundation of China (NSFC) [21202148]
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Diaryliodonium salts are powerful and widely used arylating agents in organic chemistry. Here we report a scalable synthesis of densely functionalized diaryliodonium salts from aryl iodides under mild conditions. This two-step, one-pot process has remarkable functional group tolerance, is compatible with commonly employed acid-labile protective group strategies, avoids heavy metal and transition metal reagents, and provides a direct route to stable precursors to PET imaging agents.
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