Journal
CHEMMEDCHEM
Volume 12, Issue 4, Pages 288-291Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201600580
Keywords
amidinoureas; breast cancer; cell proliferation; MDA-MB-231 cells; triazines
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Funding
- Royal Society of Chemistry
- Northumbria University
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A series of novel amidinourea derivatives was synthesized, and the compounds were evaluated as inhibitors of MDA-MB-231 human breast cancer cell proliferation. In addition, a second series of triazine derivatives designed as rigid congeners of the amidinoureas was synthesized, and the compounds were evaluated for their antiproliferative activity. Among the two series, amidinourea 3d (N-[N-[8-[[N-(morpholine-4-carbonyl)carbamimidoyl]amino]octyl]carbamimidoyl]morpholine-4-carboxamide) emerged as a potent anticancer hit compound with an IC50 value of 0.76m, similar to that of tamoxifen.
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