Journal
CHEMMEDCHEM
Volume 12, Issue 7, Pages 487-501Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201700044
Keywords
drug design; kinase inhibitors; medicinal chemistry; pharmacophores; sulfoximines
Categories
Ask authors/readers for more resources
Sulfoximines have gained considerable recognition as an important structural motif in drug discovery of late. In particular, the clinical kinase inhibitors for the treatment of cancer, roniciclib (pan-CDK inhibitor), BAY1143572 (P-TEFb inhibitor), and AZD6738 (ATR inhibitor), have recently drawn considerable attention. Whilst the interest in this underrepresented functional group in drug discovery is clearly on the rise, there remains an incomplete understanding of the medicinal-chemistry-relevant properties of sulfoximines. Herein we report the synthesis and invitro characterization of a variety of sulfoximine analogues of marketed drugs and advanced clinical candidates to gain a better understanding of this neglected functional group and its potential in drug discovery.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available