Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 13, Pages 3579-3584Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201610273
Keywords
amide bond formation; fluorescent labeling; glycoalbumin; gold catalysis
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Funding
- JSPS KAKENHI [JP16H03287, JP16K13104, JP15H05843]
- Russian Government Program of Competitive Growth of Kazan Federal University among World's Leading Academic Centers
- Grants-in-Aid for Scientific Research [16K13104, 16H03287, 26221204, 15H05843, 26560438] Funding Source: KAKEN
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Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin-Au-III complex was designed and developed that enables organ-specific, localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5- and TAMRA-linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.
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