Journal
CANCER LETTERS
Volume 391, Issue -, Pages 12-19Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2017.01.010
Keywords
Long noncoding RNA; Gene expression; Cancer
Categories
Funding
- National Health and Medical Research Council project grants
- Australian Research Council Future Fellowship
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With the advances in genomic analysis technologies, especially next-generation RNA sequencing, a large number of new transcripts have been discovered, leading to better understanding of long noncoding RNAs (IncRNAs). Recent investigations have provided firm evidence for the critical roles of IncRNAs in chromatin modification, gene transcription, RNA splicing, RNA transport and translation. In vitro and in vivo studies have also proven that aberrant lncRNA expression is essential for the initiation and progression of cancers. Due to their unique tissue- and cancer-specific expression profiles, aberrant expression of IncRNAs can be used as reliable prognostic markers for cancer diagnoses and treatment stratification, and lncRNAs are novel therapeutic targets with high therapeutic windows. (C) 2017 Elsevier B.V. All rights reserved.
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