Journal
CHEMSUSCHEM
Volume 10, Issue 7, Pages 1360-1363Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.201700153
Keywords
gabapentin; ionic liquids; l-glutamic acid; mechanochemistry; pharmaceutical
Funding
- Fundacao para a Ciencia e a Tecnologia [UID/QUI/00100/2013, SFRH/BD/93140/2013]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/93140/2013] Funding Source: FCT
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An alternative, efficient, and green synthetic strategy for the preparation of pharmaceutical ionic liquids using mechanochemistry (MechanoAPI-ILs) is reported. Six new API-ILs based on gabapentin and l-glutamic acid were successfully synthesized and characterized, demonstrating that mechanochemistry is a very promising synthetic strategy. Results compare both the new and the classical approach and clearly show the advantages of the new method. This new technique is faster, solvent free, reproducible, selective, and leads to higher yields.
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