Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 16, Pages 4549-4553Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201700446
Keywords
C-11-labeling; carbonylation; palladium; peptides
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Funding
- Danish National Research Foundation [DNRF118]
- Aarhus University
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A mild and effective method is described for C-11-labeling of peptides selectively at the N-terminal nitrogen or at internal lysine positions. The presented method relies on the use of specific biphosphine palladium-methyl complexes and their high reactivity towards amino-carbonylation of amine groups in the presence [C-11] carbon monoxide. The protocol facilitates the production of native N-C-11-acetylated peptides, without any structural modifications and has been applied to a selection of bioactive peptides.
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