Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 23, Issue 21, Pages 4967-4972Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201605948
Keywords
DNA; RNA-quadruplexes; ESIPT; light-up probes; luminescence; ruthenium complexes
Categories
Funding
- Fonds National de la Recherche Scientifique [FRS-FNRS-FRFC 2.4.530.12]
- Fonds Van Buuren & Fondation Jaumotte-Demoulin
- Labex ARCANE [ANR-11-LABX-0003-01]
- COST action [CM1202]
- Michel Kaisin travel grant
- Lycee Le Castel
- CNRS
- Universite de Bourgogne
- Conseil Regional de Bourgogne (3MIM project)
Ask authors/readers for more resources
A series of Ru-II complexes exhibiting -extended, acridine-based ancillary chelating heterocycles display high affinity and selectivity for DNA and RNA quadruplexes. The most promising candidates (3, 4) possess remarkable light-up luminophore properties (up to 330-fold luminescence enhancement upon interaction with quadruplexes), enabling them to discriminate quadruplexes from genomic DNA owing to a photochemical mechanism involving DNA protection against non-radiative decay (DAND), thus deviating from the other complexes of this series of ligands that exhibit an excited-state intramolecular proton transfer (ESIPT) that quenches their luminescence. The in vitro and preliminary in cellulo results shown here confirm the interest of this new family of fluorophores as invaluable molecular tools to detect G-quadruplexes in cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available