Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 28, Pages 3941-3944Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc00029d
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Funding
- National Natural Science Foundation of China [21471134, 21571158]
- Innovation Scientists and Technicians Troop Construction Projects of Henan [152101510003]
- Plan for Scientific Innovation Talent of Henan Province [154200510011]
- Program for Science and Technology Innovative Research Team in University of Henan Province [15IRTSTHN002]
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Tunable electrochemical biosensors based on analogous Zr-MOFs were developed for protein detection, the performances of which rely on the pore sizes and surroundings of the MOFs that show diverse binding behaviors to aptamers and then the targeted proteins. The optimized Zr-MOF-based sensor has high selectivity to lysozyme in a wide concentration range and a low detection limit of 3.6 pg mL(-1), with good repeatability, stability, and applicability in real samples. This work will establish a new platform for biosensing and extend the application scope of MOF materials.
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