Journal
ANTICANCER RESEARCH
Volume 37, Issue 3, Pages 1067-1074Publisher
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.11418
Keywords
Rhabdomyosarcoma; cisplatin; histone deacetylase inhibitors; VPA; SAHA; isobolographic analysis
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Background/Aim: The aim of this study was to assess the anticancer effect and the type of pharmacologic drug-drug interaction of cisplatin (CDDP) and histone deacetylase inhibitors (HDIs) combined treatment on the rhabdomyosarcoma cell line. Materials and Methods: The antiproliferative actions of cisplatin and suberoylanilide hydroxamic acid (SAHA, vorinostat), as well as valproic acid (VPA) alone and in combination, were evaluated using the tetrazolium dye-based MTT cell proliferation assay and isobolographic analysis. Results: All tested compounds inhibited proliferation of rhabdomyosarcoma cancer cells in a dose-dependent manner. The combinations of CDDP with SAHA and CDDP with VPA produced additive interaction with type-I isobolographic analysis. Conclusion: When adding SAHA or VPA to CDDP therapy, one can expect additive anticancer effects in the rhabdomyosarcoma cell line.
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