Journal
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
Volume 203, Issue -, Pages 108-112Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autneu.2016.12.008
Keywords
Sympathetic baroreflex; Muscle sympathetic nerve activity (MSNA); Microneurography; Threshold-analysis; Systemic vascular resistance
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Funding
- Ministry of Science and Higher Education (Poland)/Wroclaw Medical University [ST-915]
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Background: Evaluation of sympathetic baroreflex (sBR) function in humans requires intra-neural recording of muscle sympathetic nerve activity (MSNA) by microneurography. Aims: We proposed noninvasive approach for the evaluation of sBR function by applying the threshold-analysis (traditionally, based on MSNA) to systemic vascular resistance (SVR) measurement by photoplethysmography. Methods & results: In nine healthy subjects (5 M; age: 25 +/- 5y), the threshold-analysis was calculated twice: using MSNA and SVR. Both methods yield comparable results in men (T-50(hurst-vs.-svr): CV = 8.8%, r > 0.9; Slope(burst-svr): CV = 30.1%; r > 0.9), but not in women. Conclusions: SVR-based threshold-analysis is feasible in healthy young subjects and provides a promising alternative to the traditional MSNA-based approach. (C) 2017 Elsevier B.V. All rights reserved.
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