Organocatalysis on Tap: Enantioselective Continuous Flow Processes Mediated by Solid-Supported Chiral Organocatalysts

Sustainability concerns are reshaping the way chemists work, not only at the stage of process design, but also when actually performing reactions. This change in outlook is exemplified by the deployment of continuous flow techniques, which is slowly becoming mainstream practice. Indeed, the possibility of performing catalytic processes (the flagship of sustainable chemistry) in flow presents distinctive advantages. Thus, several authors are focusing their efforts on trying to get the best of these two worlds, with the consequent challenge of finding common solutions for their corresponding issues. In the last few years, this approach has been taken one step further with the use in flow processing of enantioselective organocatalysts, which allow the production of enantiopure compounds free of metal contaminants. Here we cover the literature relating to the use of solid-supported organocatalysts for the continuous flow production of enantiomerically enriched compounds.