Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 322, Issue -, Pages 299-310Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2016.06.035
Keywords
Aging; Longevity; Cognitive aging; Model systems; Cognitive decline
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Cognitive decline is a major deficit that arises with age in humans. While some research on the underlying causes of these problems can be done in humans, harnessing the strengths of small model systems, particularly those with well-studied longevity mutants, such as the nematode C. elegans, will accelerate progress. Here we review the approaches being used to study cognitive decline in model organisms and show how simple model systems allow the rapid discovery of conserved molecular mechanisms, which will eventually enable the development of therapeutics to slow cognitive aging. (C) 2016 Elsevier B.V. All rights reserved.
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