Journal
CURRENT HYPERTENSION REPORTS
Volume 19, Issue 3, Pages -Publisher
SPRINGER
DOI: 10.1007/s11906-017-0718-1
Keywords
Genetics of hypertension; Gene-environment; Phenotypes; Cardiovascular disease
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Purpose of Review Here, we discuss the interpretation and modeling of gene-environment interactions in hypertensionrelated phenotypes, with a focus on the necessary assumptions and possible challenges. Recent Findings Recently, small cohort studies have discovered several novel genetic variants associated with hypertension-related phenotypes through modeling gene-environment interactions. Several consortia-based meta-analytic efforts have uncovered many novel genetic variants in hypertension without modeling interaction terms, giving promise to future meta-analytic efforts that incorporate gene-environment interactions. Summary Heritability studies and genome-wide association studies have established that hypertension, a prevalent cardiovascular disease, has a genetic component that may be modulated by the environment (such as lifestyle factors). This review includes a discussion of known genetic associations for hypertension/blood pressure, including those resulting from the incorporation of gene-environmental interaction modeling.
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