Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2015, Issue 30, Pages 6710-6726Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201500931
Keywords
Antioxidants; Nucleophilic substitution; Azides; Nitrogen heterocycles; Polyphenols
Categories
Funding
- Regione Liguria
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Hydroxytyrosol, a natural polyphenol that can be extracted from olive mill waste waters, was converted into a series of more complex and lipophilic analogues by conjugation with other naturally derived (poly)phenolic fragments. Ether and triazole linkers were employed. A small library of compounds was prepared, stressing step economy and operational simplicity. Some of these substances were proven to have activity equal or superior to that of the parent hydroxytyrosol in radical scavenging assays as well as in cytotoxicity tests against tumour cells.
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