Journal
JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY
Volume 2017, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2017/8704639
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Funding
- National Natural Science Foundation of China [31271929, 31300720]
- Science and Technology Project of Lianyungang City [SH1244]
- Six Talent Peaks Project in Jiangsu Province
- Jiangsu Provincial Government Scholarship Project
- Science and Technology of Jiangsu Marine Resources Development Research Institute [JSIMR201309, JSIMR201505]
- 521 Project
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A rapid and simple method was optimized and validated for the separation and quantification of paraquat, a frequently used herbicide and a leading cause of fatal poisoning worldwide, at trace levels with UV-Vis spectrophotometry in plasma and urine samples by direct magnetic solid-phase extraction. Fe3O4@SiO2 nanoparticles (NPs) were used as the magnetic solid-phase extraction agents and the paraquat absorbed on NPs was eluted using NaOH and ascorbic acid. Upon optimization, paraquat could be extracted and concentrated from various samples by 35-fold. The linear range, limit of detection (LOD), correlation coefficient (R), and relative standard deviation (RSD) could reach 15.0-400.0 mu g/L, 12.2 mu g/L, 0.9987, and 0.65% (n = 5, c = 40.0 mu g/L), respectively. The Fe3O4@SiO2 NPs could be reused up to five times. The method was successfully applied to the determination of paraquat in urine and plasma at different hemoperfusion numbers in a local hospital for the patient of paraquat poisoning. The experiment result could not only enable immediate medical intervention but also benefit patients' survival.
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