Journal
DRUG DISCOVERY TODAY
Volume 22, Issue 3, Pages 503-509Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2016.09.010
Keywords
-
Categories
Ask authors/readers for more resources
Tuberculosis (TB) is a global epidemic associated increasingly with resistance to first-and second-line antitubercular drugs. The magnitude of this global health threat underscores the urgent need to discover new antimycobacterial agents that have novel mechanisms of action (MOA). In this review, we highlight some of the key advances that have enabled the strengths of target-led and phenotypic approaches to TB drug discovery to be harnessed both independently and in combination. Critically, these promise to fuel the front-end of the TB drug pipeline with new, pharmacologically validated drug targets together with lead compounds that act on these targets.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available