Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 27, Issue 5, Pages 1220-1224Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2017.01.060
Keywords
Klyxum flaccidum; Steroid; Klyflaccisteroid; Cytotoxicity; Anti-inflammatory activity
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Funding
- Ministry of Science and Technology [MOST 104-2320-B-110-001-MY2, MOST 104-2113-M-110-006]
- NSYSU-KMU Joint Research Project [NSYSUKMU 105-I008]
- Aim for the TOP University Program from Ministry of Education of Taiwan [04C030205, 05C030205]
- Taiwan Protein Project [MOST105-0210-01-12-01]
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New steroids, klyflaccisteroids K-M (1-3), were isolated from a soft coral Klyxum flaccidum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Klyflaccisteroid K (1) is the unique 9,11-secosteroid with a 5,8-epidioxy-9-ene functional group. Klyflaccisteroid L (2) has an unusual 11-norsteroid skeleton and is the first example of 11-oxasteroid isolated from natural sources. Cytotoxicity assay showed that 1 and 3 possessed moderate to weak cytotoxicity against these cancer cells. Compound 1 was also found to display significant anti-inflammatory activity of suppressing superoxide anion generation (O-2(-center dot)) and elastase release, and compound 3 was found to show notable anti-inflammatory activity toward inhibition of elasstase release, too. (C) 2017 Elsevier Ltd. All rights reserved.
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