Journal
BIOORGANIC CHEMISTRY
Volume 70, Issue -, Pages 153-162Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2016.12.006
Keywords
Schiff base; Nanotechnology; Nano-formulation; PEG; Antifungal agent
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Fungal diseases posing a severe threat to the production of pulses, a major protein source, necessitates the need of new highly efficient antifungal agents. The present study was aimed to develop azomethine based nano-fungicides for protecting the crop from fungal pathogens and subsequent yield losses. The protocol for the formation of nano-azomethines was generated and standardized. Technically pure azomethines were transformed into their nano-forms exploiting polyethylene glycol as the surface stabilizer. Characterization was performed by optical (imaging) probe (Zetasizer) and electron probe (TEM) characterization techniques. The mean particle sizes of all nano-fungicides were below 100 nm. In vitro fungicidal potential of nano-chemicals was increased by 2 times in comparison to that of conventional sized azomethines against pathogenic fungi, namely, Rhizoctonia solani, Rhizoctonia bataticola and Sclerotium rolfsii. The performance of nano-chemicals in pot experiment study was also superior to conventional ones as antifungal agent. (C) 2016 Elsevier Inc. All rights reserved.
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