4.8 Article

Collagen-Based Photoactive Agent for Tissue Bonding

Journal

ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 11, Pages 9265-9270

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b01984

Keywords

tissue photobonding; rose Bengal; collagen; wound healing; cross-linking

Funding

  1. Natural Sciences and Engineering Research Council (NSERC) [RGPIN- 2015-0632, 342107]
  2. AFA Forsakring, Sweden
  3. UOHI start-up grant [1255]
  4. Burroughs Wellcome Fund

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Using a combination of methacrylated, collagen and the photosensitizer rose Bengal, a new light-activated biomimetic material for tissue sutureless bonding was developed. This formulation was cross-linked using green light. In vivo tests in mice demonstrate the suitability of the material for sutureless wound closure.

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