Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 11, Pages 9260-9264Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b01609
Keywords
multifunctional cationic polymer; reactive oxygen species; photosensitizer; selective antibacterial activity; lysosome-specific imaging
Funding
- National Natural Science Foundation of China [21504002]
- Beijing Technology and Business University fund project [LKJJ2016-20]
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In this work, a cationic polymer was synthesized to bear quaternized N-methyl-imidazole groups in the side chains. Positively charged PPV-M could selectively bind to Gram-negative and Gram-positive bacteria over fungi and exhibit enhanc6d antibacterial activity with the aid of white light because PPV-M could sensitize oxygen to generate reactive oxygen spedes (ROS) that would damage bacteria. In addition, green fluorescent and positively charged PPV-M has the ability to enter mammalian cells and be specifically accumulated in lysosome. Moreover, PPV-M could stay in live cells for a relatively long time, which implies that PPV-M has the potential to be a long-term imaging agent.
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