Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 17, Pages 4824-4828Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201700696
Keywords
alkynes; copper; heterocycles; multicomponent reactions; synthetic methods
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Funding
- National Natural Science Foundation of China [21372138, 21672120]
- National Key Research and Development Program of China [2016YFB0401400]
- Fok Ying Tong Education Foundation of China [151014]
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A [2+2+2] modular synthesis of multisubstituted pyridines, with excellent regioselectivity, has been realized by copper catalysisand involves three distinct components: vinyliodonium salts, nitriles, and alkynes. The reactions proceeded with the facile formation of an aza-butadienylium intermediate by alkenylation of the nitrile with a vinyliodonium salt. Moreover, the alkynes in the reaction were extended to alkenes, which are an advantage of expense and relative scarceness of alkynes.
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