Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 29, Pages 4092-4095Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc01133d
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Funding
- National Natural Science Foundation of China [81572086, 21275110, 21535005]
- Wuhan Municipal Basic Research Project [2016060101010052]
- 863 Program [2013AA032204]
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We report a single-microsphere based imaging assay method by integrating up-converting luminescence with optical tweezers for detecting microRNA-21 sequences. This method achieves a competitive detection limit of 12 fM with good selectivity and no dedicated signal amplification designs.
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