Journal
DEVELOPMENT
Volume 144, Issue 8, Pages 1382-1398Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.148270
Keywords
Androgen signaling; Development; Differentiation; Induction; Prostate
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Funding
- Australian National Health and Medical Research Council Early Career Fellowship
- National Institutes of Health [R01DK076602]
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Prostate organogenesis is a complex process that is primarily mediated by the presence of androgens and subsequent mesenchyme-epithelial interactions. The investigation of prostate development is partly driven by its potential relevance to prostate cancer, in particular the apparent re-awakening of key developmental programs that occur during tumorigenesis. However, our current knowledge of the mechanisms that drive prostate organogenesis is far from complete. Here, we provide a comprehensive overview of prostate development, focusing on recent findings regarding sexual dimorphism, bud induction, branching morphogenesis and cellular differentiation.
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