Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 17, Pages 4734-4738Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201701329
Keywords
cyclization; electrochemistry; ferrocene; radicals; redox chemistry
Categories
Funding
- MOST [2016YFA0204100]
- NSFC [21672178, 21402164]
- Thousand Youth Talents Plan
- XMU
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Reported herein is an unprecedented synthesis of C3-fluorinated oxindoles through cross-dehydrogenative coupling of C(sp(3))-H and C(sp(2))-H bonds from malonate amides. Under the unique and mild electrochemical conditions, the requisite oxidant and base are generated in a continuous fashion, allowing the formation of the base-and heat-sensitive 3-fluorooxindoles in high efficiency with broad substrate scope. The synthetic usefulness of the electrochemical method is further highlighted by its easy scalability and the diverse transformations of the electrolysis product.
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