4.7 Article

An endoplasmic reticulum-selective ratiometric fluorescent probe for imaging a copper pool

Journal

CHEMICAL COMMUNICATIONS
Volume 53, Issue 32, Pages 4457-4460

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc01430a

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Funding

  1. Korean National Research Foundation (NRF) [2015R1C1A2A01054496, 2014R1A2A1A11052325]
  2. Sookmyung Women's University Research Grants [1-1603-2026]
  3. National Research Foundation of Korea [2015R1C1A2A01054496, 2014R1A2A1A11052325] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Hydrazide-linked naphthalimides undergo copper ion-selective hydrolysis with concomitant ratiometric fluorescence change. In addition, probe 1 is biocompatible and mainly localized to the endoplasmic reticulum ( ER) in live HeLa cells. It thus can be used for imaging copper accumulation in the ER of live cells, as implied in copper-overloaded situations.

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