4.3 Review

Potential Use of Cyclodextrins as Drug Carriers and Active Pharmaceutical Ingredients

Journal

CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 65, Issue 4, Pages 341-348

Publisher

PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c16-00779

Keywords

cyclodextrin (CyD); drug delivery system (DDS); active pharmaceutical ingredient; non-viral vector; supramolecule

Funding

  1. Japan, Society for the Promotion of Science [16K15322]
  2. Uehara Memorial Foundation
  3. [16590114]
  4. [18590144]
  5. [20590037]
  6. [16H05223]
  7. Grants-in-Aid for Scientific Research [16K15322] Funding Source: KAKEN

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Cyclodextrins (CyDs) are extensively used in various fields, and especially have been widely utilized as pharmaceutical excipients and drug carriers in the pharmaceutical field. Owing to the multi -functional and biocompatible characteristics, CyDs can improve the undesirable properties of drug molecules. This review outlines the current application of CyDs in pharmaceutical formulations, focusing on their use as CyD-based drug carriers for several kinds of drugs. Additionally, CyDs have great potential as active pharmaceutical ingredients against various diseases with few side effects.

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