4.4 Article

211Rn/211At and 209At production with intense mass separated Fr ion beams for preclinical 211At-based α-therapy research

Journal

APPLIED RADIATION AND ISOTOPES
Volume 122, Issue -, Pages 222-228

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2017.01.035

Keywords

astatine-211; At-211; astatine-209; At-209; radon-211; radon-211; francium; radioisotope production; generator system; targeted alpha therapy; ISOL-technique, rare isotope beam; ion implantation

Funding

  1. Innovation Grant from the Canadian Cancer Society Research Institute [702437]

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Mass-separated francium beams (Fr-211 or Fr-213) were implanted into solid targets for producing Rn-211 (14.6 h half-life) or At-209 (5.41 h), in situ. Rn-211 was transferred to dodecane and isolated from contaminants, providing sources for At-211 (7.21 h) production by Rn-211 decay (73%). At-209 was recovered with high radionuclidic purity in aqueous solutions, directly. These experiments demonstrated Fr beam implantations as a novel method for producing preclinical quantities of Rn-211/(211) Fit (for therapy) and At-209 (for imaging).

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