Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 65, Issue 4, Pages 403-407Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c16-00798
Keywords
Alismatis Rhizoma; Alisma orientale; guaiane-type sesquiterpenoid; anti-inflammatory
Funding
- National Natural Science Foundation of China [U1502223, 31560103]
- National Basic Research Program of China (973 Program) [2011CB915503]
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Twelve guaiane-type sesquiterpenoids, including four new ones, 10-O-methyl-orientalol A (1), 10-O-ethyl-alismoxide (2), 3 beta,4 beta-expoxy-chrysothol (3), orientalol G (4), and a new norsesquiterpenoid, orientalol H (5), were isolated from Chinese Alismatis Rhizoma, the dried rhizome of Minna orientale. The structures of new compounds were elucidated on the basis of spectroscopic data. Moreover, the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells of all compounds was tested.
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