Journal
HUMAN VACCINES & IMMUNOTHERAPEUTICS
Volume 14, Issue 1, Pages 81-84Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21645515.2017.1386360
Keywords
Staphylococcus aureus; capsular polysaccharide; vaccine; antibody response; O-acetylation
Categories
Funding
- Pfizer
Ask authors/readers for more resources
Staphylococcus aureus produces an antiphagocytic polysaccharide capsule to evade neutrophil-mediated killing. Many vaccines against encapsulated bacterial pathogens require generation of functional anti-capsular antibodies to mediate protection against infection and disease. Here it is shown that the generation of such antibody responses to S. aureus in vivo and in vitro requires the presence of O-acetyl modifications on the capsular polysaccharides. O-acetylation of S. aureus capsular polysaccharide therefore should be monitored carefully during vaccine development and production. This finding may provide additional insight into the previous failure of a S. aureus capsular polysaccharide conjugate vaccine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available