Journal
BIOMOLECULES
Volume 7, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/biom7010003
Keywords
DNA methylation; histone methylation; DNMT; HMT crosstalk; DNMT inhibitors; HMT inhibitors
Categories
Funding
- Centre National de la Recherche Scientifique (CNRS)
- PlanCancer (AAP Epigenetique et Cancer)
- Ecole Doctorale Biologie Sante de Lille
- National Council of Science and Technology (CONACYT, Mexico)
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Chromatin can adopt a decondensed state linked to gene transcription (euchromatin) and a condensed state linked to transcriptional repression (heterochromatin). These states are controlled by epigenetic modulators that are active on either the DNA or the histones and are tightly associated to each other. Methylation of both DNA and histones is involved in either the activation or silencing of genes and their crosstalk. Since DNA/histone methylation patterns are altered in cancers, molecules that target these modifications are interesting therapeutic tools. We present herein a vast panel of DNA methyltransferase inhibitors classified according to their mechanism, as well as selected histone methyltransferase inhibitors sharing a common mode of action.
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